Granada Health-Science Technology Park
Life Sciences and Health, Agrifood, Environmental Biotechnology, Bioinformatics, Other Technologies
Lourdes Nuñez Müller, MBA, PhD Director of Knowledge Transfer
Address: C/ Recogidas, 24 Portal B Esc A 1ºB
Phone: 34 958535050
Fax: 34 958258001
The Granada Health Science Technological Park is exceptionally situated to the south of the capital city of Granada, a university city with a long tradition in healthcare, biomedicine and life sciences.
The Health Science Technological Park is an ideal resource for the creation, implementation and expansion of institutes and companies, which converts knowledge into economic and social development, especially in the Pharmaceutical, Health Sciences, Healthcare and Food industries, making it the first park specialised in healthcare in Spain and one of very few throughout the world.
PTS Granada benefits from the University of Granada’s experience and history in the health sciences field, which gives the park an innovative feel. The park has the facilities necessary to offer all the benefits of a modern technological space and aims to integrate the fields of Health Care, Business Development, Research and Teaching with a particular focus on Health and Biomedicine.
PTS covers an area of 625,000 m² with 350,000 m² of building land for the different areas of the park.
PTS Granada is a model for the transfer of basic clinical Research and Technology in the field of health and biomedicine which contributes to economic development via:
The promotion of interdisciplinary research in biomedicine at an international level in order to make medical advances through the understanding, diagnosis, treatment, cure and prevention of illnesses.
The protection and transfer of knowledge generated especially in the field of health and biomedicine.
The consolidation of a consolidación de un tejido health sciences business framework based on technology and aimed at clinical practice.
Being a centre of excellence for healthcare which meets the healthcare needs of patients.
The Health Science Technological Park, which was created with the aim of becoming the first ever Health Campus, is supported by: the Autonomous Government of Andalusia via its Ministries for Innovation, Science and Business, Health, and Public Works and Transport; the University of Granada; the councils of Granada and Armilla; the Provincial Council of Granada; the Spanish Council for Scientific Research (CSIC); the banks Caja Granada and Caja Rural; the Granada Confederation of Entrepreneurs (CGE); and the Granada Chamber of Commerce, Industry and Navigation
Of the 625,000m² which make up the total surface area of the Health Science Technological Park, 110,000m² is used to house buildings dedicated to research, development and innovation, 120,000m² for healthcare purposes and 98,000m² for teaching purposes.
Public facilities in the Park include 6000 parking spaces, transport links to the centre of Granada and to Armilla via bus or line 1 of the underground which will open to passengers in 2009.
The park has an underground services and facilities gallery covering an area of 3600m² and which is 2.5 metres high and 2.5 metres wide, which is used by each and every one of the buildings within the PTS. The gallery was designed to incorporate infrastructures for other energy sources and services, such as a high capacity fibre optic network providing the Park with the latest telecommunication technologies.
The Health Science Technological Park, which currently employs more than 500 workers, has already become one of the biggest employers throughout the province of Granada. This figure represents a quarter of the total number of jobs which the biomedical centre is estimated to provide when all its centres are working to full capacity, which will be around the year 2010.
In the Research and Development and Innovation area of the Health Science Technological Park, the European Business Innovation Centre (BIC Granada) is used by 37 companies employing a total of 243 people.
The López Neyra Parasitology and Biomedicine Institute employs over one hundred researchers.
The Advanced Multifunctional Centre for Simulation and Technological Innovation (SMAT) employs 25 people, not including the education professionals contracted in order to cover the needs of training programmes.
About 14,000 people will work in healthcare, research, teaching and other business areas in the different parts of the Health Science Technological Park:
New university faculties: Medicine, Pharmacy, Dentistry, Health Sciences
Biomedical Research Centre
Pharmaceutical and Food Development Centre
Servilens Fit and Cover
PTS Business Centre
Andalusian Institute of Legal Medicine
RESEARCHThe Health Science Technological Park promotes initiatives which help to further basic clinical research in the field of health and biomedicine using its prestigious, advanced research centres, placing Granada at the forefront of biotechnology and health research.
The PTS is a technological space which helps strengthen the relationships between researchers and people working in the healthcare and financial sectors. In this way, the university community can make the results of its research as useful and profitable as possible.
The combined scientific and technological resources available in the PTS create an excellent environment for the creation of synergies and offer an ideal location for companies in the biotechnology and health sectors. All biomedical companies must be able to work in a university-level scientific environment in order to develop state-of-the-art projects and innovations, and the PTS provides the perfect location for this purpose.
Thanks to its prestigious and advanced research centres, the Health Science Technological Park can promote research in the biotechnological and health care sectors.
Biomedical Research Center.
Biomedicine and Parasitology Institute “López-Neyra”.
Andalusian Institute of Legal Medicine.
Crystallography Research Laboratory.
This Centre, which has a budget of over 10 million euros, employs groups of highly qualified researchers and aims to put the autonomous region of Andalusia at the forefront of biomedical research in Europe. The Centre houses the first Stem Cell Bank in Spain (BANCELAN). This bank will open up another line of revolutionary biomedical research which will be applied to regenerative medicine. Research groups from the following organisations have their headquarters in the Biomedical Research Centre:
Federico Olóriz Neuroscience Institute
Institute of Nutrition and Food Technology
Institute of Biopathology and Regenerative Medicine
This Institute was created in 1989 and employs 47 researchers in 15 research groups. The Institute has produced more than 856 international publications and has registered 14 patents.
Federico Olóriz Neuroscience Institute
The Federico Olóriz Neuroscience Institute employs researchers in research groups in 11 different departments (belonging to 4 faculties) in the University of Granada, and carries out multidisciplinary research including in vitro studies of neuronal cultures and sub-cellular fractions, in vivo studies on animals and clinical studies on humans.
Institute of Nutrition and Food Technology
The University of Granada’s Institute of Nutrition and Food Technology is a multidisciplinary Institute and its members come from different research backgrounds, mainly from the fields of Molecular Biology and Biochemistry, Physiology, Nutrition and Bromatology, Microbiology and the Teaching of Experimental Sciences. Its research activities are centred around different aspects of Human Nutrition and the Design of functional and healthy foods. The Institute is structured around research groups and employs a total of 48 researchers.
Research Carried out by the Institute:
The López Neyra Parasitology and Biomedicine Institute (IPBLN), which is based in PTS Granada, forms part of the Spanish Council for Scientific Research. Its research activities are centred around the field of biomedical sciences, specifically in the areas of immunology, molecular and cellular biology, and infectious diseases. The Institute is currently made up of three departments and has eighteen research groups.
The Institute aims to study biomedical processes and organisms which are of particular importance in the field of global diseases. The centre is also involved in training activities. It collaborates in the teaching of Specialisation Courses, Doctorate Programmes and also takes on many doctorate students who carry out research for their doctorate theses in the Institute.
Representative Results Obtained:
It is important to point out that the results of the work carried out by the Institute’s central services are not only available to its own researchers but also to the scientific community as a whole. The DNA sequencing, oligonucleotide synthesis and cell culture services deserve special mention, but recognition must also be given to those people whose day-to-day work means that the centre can continue to function and develop so that it remains at the forefront of the field of international biomedical research.
The IPBLN develops tools which can prevent, detect and treat infectious, autoimmune and degenerative diseases.
Its researchers work in laboratories to study diseases such as malaria, Parkinson’s disease, arthritis, AIDS, multiple sclerosis, sleeping sickness, leishmaniasis, lupus and hepatitis C.
One of its research teams has proposed a type of cellular therapy to make the symptoms of rheumatoid arthritis and multiple sclerosis disappear without the need to take any medicines.
Another IPBLN team has identified relevant immunogenic proteins and immunomodulating molecules which can help combat Chagas disease, a potentially fatal illness spread by parasites which affects 17 million people worldwide.
IPBLN researchers work in collaboration with several hospitals in Andalusia and the rest of Spain, such as the Torrecárdenas Hospital in Almería, the Ruiz de Alda Clinical Hospital in Granada, the Ramón y Cajal and Carlos III hospitals in Madrid, and the Clinical Hospital in Barcelona. They have obtained numerous patents and signed several contracts to collaborate with pharmaceutical and biotechnology companies. The IPBLN researchers also hold exploitation licenses for the results obtained in their experiments.
ANDALUSIAN INSTITUTE OF LEGAL MEDICINE This Institute includes the forensic pathology service, the forensic medical clinic, the forensic laboratory, the headquarters for the teaching and research commission, as well as management and administrative services. In association with the Spanish National Toxicology Institute, the IML provides high quality services for laboratory and clinical research for the region of Andalusia. The IML also works with the Andalusian Centre of Excellence for Forensic Research, which coordinates and promotes scientific research and specialised training in forensic sciences throughout Andalusia. The building, which is located next to the new University Hospital, covers an area of 3,400 m² and has a construction budget of five million euros.
CRYSTALLOGRAPHY RESEARCH LABORATORY
Research Carried out by the Laboratory
The Crystallography Research Laboratory (LEC) is a research unit belonging to the Spanish Council for Scientific Research (CSIC). The centre specialises in research into crystallographic problems, and generally uses natural materials. The LEC has achieved particular success in the fields of crystal growth in diffusive mediums, the formation of self-organised patterns, X-ray diffraction characterisation of crystalline materials, biomineralisation and the origin of life. Just as the variety of subjects studied is wide, so is that of the techniques employed, ranging from basic science to the application and development of new technology. The following are examples of the research programmes which best represent the activities carried out in the LEC:
- Crystallisation of biological macromolecules and drugs.
- Characterisation using synchrotron radiation.
- Biomineralisation and biomimetic materials.
- Formation of self-organised patterns.
- Origin of life and detection of primitive life.
- Intermolecular interactions and molecular recognition.
- Crystalline polymorphism of bioactive compounds.
Representative Results Obtained
The LEC has carried out extensive research over recent years. This research is reflected in the publication of results in specialised magazines, the carrying out of national and European scientific and technical projects, the giving of speeches in conferences, the organisation of courses, conferences and other events, and the signing of collaborative and advisory contracts with companies and other bodies.
Most importantly, the LEC is currently the leading international laboratory for research into crystallisation on space platforms. In this field, two complementary strategic lines of research are carried out: basic studies into the science of crystallisation, and applied studies which aim to develop high-capacity crystallisation techniques using solutions in microgravity situations. One of the three devices currently available in the International Space Station for use by European and Japanese Space Agencies was developed by the LEC, and the laboratory helped to develop and test the other two devices.
Triana Science & Technology, which is based in PTS Granada, is a spin-off company promoted by the LEC which manufactures and markets crystallisation technologies.
There are two sides to the technology transfer activities carried out by the LEC: firstly, we transfer our experience and technical abilities via research and advisory contracts with other companies, and secondly, we develop new crystallisation technologies. One important example of these new technologies is the new “Granada Crystallization Box (GCB)”. These newly developed technologies are often patented and licensed in order to be used by third parties.
Molecular and Cellular Biology
Neuropharmacology and pain
Neuroplasticity and Neuropsychology
Psychiatry and Neuroscience
Cephalea and drugs active on the central nervous system Neurobiology of the cerebral cortex
Biochemistry and Molecular Parasitology
Signal Transduction in Bacteria
Antagonist Substances produced by Microorganisms
Effects of Radiation
Diarthroses in Humans
Pathogenesis of Miscarriage
Development of Immunological Diseases
Nutrition and Cancer
Nutrition and the Cardiovascular System
Development of Food Products for Patients with Kidney Disease
SERVICES One of the aims of the Health Science Technological Park is to bring the needs of the industry closer to the research capabilities of the park’s centres, facilitating the transfer of ideas and technologies between both industries.
The Health Science Technological Park offers a number of services which help promote research, business development, teaching and healthcare in public and private institutions.
BUSINESS DEVELOPMENT PTS Granada is an ideal resource for the creation, implementation and expansion of institutes and companies, a space which converts knowledge into economic and social development, especially in the Pharmaceutical, Health Sciences, Healthcare and Food Industries. The Foundation that manages the Park offers a number of services which help public and private institutions to promote scientific culture, innovation and competitiveness. Some of the most important pharmaceutical companies, including Rovi Laboratories, the Telefónica R+D+i Centre of Excellence, Servilens and the Pharmaceutical and Food Development Centre, have begun construction in part of the 120,000m² of the Park assigned to business development, alongside the first Stem Cell Conservation Centre and one of the Park’s most interesting initiatives: the first Business Centre, which will house all businesses which wish to carry out their activities in PTS Granada. The first centre which opened in the PTS was the BIC Granada European Business and Innovation Centre, which aims to promote enterprise culture. Its activities range from finding new business projects to evaluating innovative projects and business. BIC Granada’s activities are overseen by the Innovation and Development Agency of the Autonomous Government of Andalusia and subsidised with European Union funds. Over three hundred people from 41 technology-based SMEs currently carry out their work from BIC Granada offices.
BIC Center Granada.
Pharmaceutical and Food Development Center.
PHARMACEUTICAL AND FOOD DEVELOPMENT CENTRE
Research Carried out by the Center:
The Pharmaceutical and Food Development Centre has two distinct R+D+I departments: one is dedicated to the development, manufacture and innovation of medicines, while the other is dedicated to the development of functional and nutraceutical foods and special diets for therapeutic use. Both these activities are carried out in the same building, sharing high-quality general services and control laboratories but using two completely separate areas of the premises. The Pharmaceutical Development Centre has the specific aims of researching and developing medicines, studying new ways in which to use drugs, manufacturing essential medicines and/or “orphan” medicines, supporting public institutions in the manufacture of batches for clinical tests and carrying out studies into bioavailability, bioequivalency, pharmacokinetics and quality control. In the field of Nutrition and Food Technologies, research is centred around the design and application of biotechnology solutions which meet the new demands of the market, such as functional foods, dietary supplements, enriched foods and diets for special groups of patients.
Representative Results Obtained:
Work on the upper floor of the R+D department will be finished before the end of this year. The laboratory aims to discover active molecules in order to evaluate their potential for use as medical drugs or nutraceuticals. In 2007, the centre aims to finish designing the different production processes which will be used as a basis for the construction of its facilities, validate them, prepare the necessary documentation and GMPs and arrange for an audit by the proper authority. In the pharmaceutical section, the capital available will make it possible to construct four different departments (solids, liquids, injectables, semi-solids) each with a good supply of sterile equipment. The equipment is made by renowned manufacturers and is of the same quality as that used by the pharmaceutical and food companies which produce the end products. The PTS has public sponsors supporting the project. The park will also include a hospital, and its pharmaceutical and food requirements will be met by the PTS.
The aim of the Pharmaceutical and Food Development Centre is to carry out technology transfer from research centres and to involve its research teams in programmes which respond to the needs of the industry. The centre will obtain its income through the provision of biotechnological services to pharmaceutical, chemical and agri-food companies. As a result, it will always be able to access and transfer innovative technologies in the Pharmaceutical and Food Biotechnology field and to bring together highly experienced experts from the pharmaceutical and food industries.
ROVI pharmaceutical laboratories, an entirely Spanish company which already has a presence in 35 countries worldwide and will soon expand to offer its range of products in 15 more, has completed the first stages of work on what will become one of the leading centres for research and manufacture of medicines in the whole of Spain. This work has been carried out in the Health Science Technological Park, which is set to become an international reference point in the world of biomedical sciences. Rovi has a production line of generic medicines and other thrombolytic medicines, is the leader in Europe for the supply of injectables and the second most important exporter of the continent. Over 18 million euros have been invested in the Granada project. The centre will provide employment for 60 specialists and will generate 1,200 kilograms of bemiparin sodium in its first year. Bemiparin is currently sold or awaiting registration in over 50 countries, making it the most important antithrombotic medicine available today. Rovi Pharmaceutical Laboratories won the 2003 Prince of Asturias Prize for Innovation for its research into heparins and the 2006 FUINSA National Laboratory Prize for its commitment to R+D+i in recognition of the development and commercialisation of bemiparin, a low molecular weight heparin for the treatment of Venous Thromboembolism (VTE). FUINSA, a non-profit organisation, hopes to strengthen biomedical research and release information about scientific, technical and health advances which aim to help society. ROVI also participates in the National Strategic Technological Research Symposiums (CENIT) programme, part of the Spanish Government’s Programa Ingenio 2010 initiative. The expected construction time is less than 18 months, so facilities could be ready to use by the end of next year. In the short term, 19 jobs will be directly created, but the premises will not be working to full capacity until 2008, when a total of 40 permanent jobs will be created for students of the University of Granada.
The R+D+i Centre of Excellence is the fifth opened by Telefónica in Spain and the first centred around the health care sector, which is the main focus of the Granada Health Science Technological Park. Telefónica will open its R+D+i Centre of Excellence in Andalusia in the PTS. The centre will create sixty direct jobs and a further forty indirect posts. The new Centre will be a point of reference in Europe for applied research into Information and Knowledge Technologies.
HOSPITALThe hospital building has been constructed on several floors with a terraced layout. This means that visitors and patients will be able to feel the sunlight coming through the windows no matter where they are in the hospital, and the building does not feel like a closed space. The hospital was built on a platform which incorporates the basement and ground floor. These floors house all of the central hospital services, including the clinical support services, the radiology department and the laboratories. All other patient consultation and in-patient services are found on the floors above this main platform. Each floor has been designed to be an independent sub-hospital. As a result, each level has its own consulting rooms, clinical offices and in-patient services. This means that patients go to the consulting room of a particular speciality, are diagnosed, operated on and admitted if necessary without having to change floors. Each floor has two distinct sections - an out-patient department and a clinical section.
The hospital has 700 bedrooms, 26 operating theatres and 132 consulting rooms. The casualty department will have an emergency room, 22 consulting rooms and 44 observation beds as well as teaching areas, laboratories and experimental operating theatres.
Specialities in the hospital include: Nuclear Medicine, Vascular Surgery, Cardiology, Digestive Medicine, Pulmonology, Radiotherapy and Oncology, Biotechnology, Pathological Anatomy and Radiodiagnosis.
A wide range of outpatient hospitals specialising in Medicine, Oncohaematology, Haemodialysis, Infectious Diseases and Surgical Operations are also available to patients, with 80 consulting and treatment centres throughout the area.
The centre stands out because of its innovative and flexible design, which can be adapted according to the changes in the healthcare industry. Each of its eight floors has consulting rooms, clinical offices and in-patient beds. A heliport on the roof means that patients or organs for transplant can be taken straight to the operating theatres via the lifts which go up to the top floor, avoiding people and vehicles which could hinder their access. The heliport will be the second of its type in Andalusia.
Work on the building, which cost 110 million euros to build, will finish in 2007. From that point on the Andalusian Health Service (SAS) will set a time limit of two years for the hospital to become fully equipped and for the transfer of services to be completed.
CMAT 061 EMERGENCIES The healthcare area of the PTS also includes an Advanced Multifunctional Centre for Simulation and Technological Innovation (CMAT), where the Public Company for Health Emergencies (EPES) has set up the largest and best equipped Emergency Coordination Centre (CCU) in Andalusia. The CCU uses a specially designed IT application developed by the EPES to store information. . The application has been designed to be available at all times, can be run 24 hours a day even when there are flaws in some of its components. Such flaws are automatically detected and corrected.
The Public Company for Health Emergencies (EPES) runs its provincial 061 emergency ambulance service from the CMAT. This service is used to coordinate responses to healthcare emergencies.
The 061 emergency ambulance service has 60 multifunctional workstations in its coordination room within the CMAT.
EACHINGThe inclusion in the healthcare complex of the faculties of Medicine, Dentistry and Pharmacy, as well as the University School of Life Sciences, which complement the existing Advanced Multifunctional Centre for Simulation and Technological Innovation (CMAT), highlights the emphasis that the people behind this ambitious project place on a complete educational background which serves to guarantee excellent results both in healthcare services as well as in the ever-changing field of biomedical and pharmaceutical research. The university teaching area, along with the shared facilities of the Central Library, the Main Hall and the General Services Building, will occupy around 25 percent of the total service area of the Health Science Technological Park, boosting the activity and dynamism of the healthcare park.